Tg(HBB-Myc)#Cos
Transgene Detail

Summary

• Symbol: Tg(HBB-Myc)#Cos
• Name: transgene insertion, Frank Costantini
• MGI ID: MGI:6323000
• Synonyms: SBM
• Transgene: Tg(HBB-Myc)#Cos Location: unknown
• Alliance: Tg(HBB-Myc)#Cos page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HBB-Myc)#Cos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: Two 72-bp repeats of the SV40 enhancer and a 687-nucleotide fragment of the human beta-globin promoter drive the expression of the mouse c-myc proto-oncogene coding region (exons 2, 3, and 3 flanking sequences). 18 lines were generated, carrying 1-30 copies of the transgene. (J:276641)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:276641 Trudel M, et al., C-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int. 1991 Apr;39(4):665-71
• All: 2 reference(s)