Secisbp2^tm1.2Amdu
Targeted Allele Detail

Summary

• Symbol: Secisbp2^tm1.2Amdu
• Name: SECIS binding protein 2; targeted mutation 1.2, Alexandra M Dumitrescu
• MGI ID: MGI:6323602
• Gene: Secisbp2 Location: Chr13:51805733-51838080 bp, + strand Genetic Position: Chr13, 26.12 cM, cytoband B1
• Alliance: Secisbp2^tm1.2Amdu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251875
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxp site was inserted upstream of exon 14 and an FRT-flanked neomycin resistance cassette and a second loxP site were inserted downstream of exon 14. Flp-mediated recombination removed the neo cassette and cre-mediated recombination deleted exon 14. (J:251875)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Secisbp2 Mutation: 56 strains or lines available

References

• Original: J:251875 Fu J, et al., Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency. Endocrinology. 2017 Dec 1;158(12):4317-4330
• All: 1 reference(s)