Tg(Myh6-BAG3*P209L)#Mswi
Transgene Detail

Summary

• Symbol: Tg(Myh6-BAG3*P209L)#Mswi
• Name: transgene insertion, Monte S Willis
• MGI ID: MGI:6324028
• Transgene: Tg(Myh6-BAG3*P209L)#Mswi Location: unknown
• Alliance: Tg(Myh6-BAG3*P209L)#Mswi page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-BAG3*P209L)#Mswi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BAG3 (9531)

  Bag3	(MGI:1352493)

  Contains the P209L mutation found in myofibrillar myopathy patients

• Mutation details: The human BAG3 cDNA with the P209L missense mutation is under the control of the alpha-MHC promoter. This mutation has been identified in myofibrillar myopathy patients. Transgene expression levels are approximately 2-fold of wild-type levels in the heart. The pound (#) sign is used when line number is not specifies or lines are pooled. (J:234278)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:234278 Quintana MT, et al., Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. Am J Pathol. 2016 Aug;186(8):1989-2007
• All: 1 reference(s)