Tg(Slc6a4-cre)#Ito
Transgene Detail

Summary

• Symbol: Tg(Slc6a4-cre)#Ito
• Name: transgene insertion, Shigeyoshi Itohara
• MGI ID: MGI:6324519
• Synonyms: 5-HTTCre Tg, Tg(Slc6a4-cre)#Rerz
• Transgene: Tg(Slc6a4-cre)#Ito Location: unknown
• Alliance: Tg(Slc6a4-cre)#Ito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc6a4-cre)#Ito expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a4 (MGI:96285)

• Mutation details: Tg construct was created by modifying the RP23-39F11 mouse BAC clone to insert the nuclear localization signal (NLS) Cre-pA cassette and FRT-Amp-FRT sequence into the translational initiation site of the Slc6a4 gene. The Amp sequence in the obtained BAC construct was removed by flp/FRT recombination in bacteria. The Tg founder mice were generated by microinjection of linearized constructs into C57BL/6 fertilized eggs. At least six lines were generated and two lines (208 and 810) were identified with similar expression patterns. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:216132)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a4 (mouse) Summary of all recombinase alleles driven by Slc6a4. Comparative matrix view of recombinase activities Alliance mouse Slc6a4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:216132 Arakawa H, et al., Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors. J Neurosci. 2014 Sep 3;34(36):12001-14
• All: 2 reference(s)