Pate4^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Pate4^tm1Osb
• Name: prostate and testis expressed 4; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6324666
• Synonyms: Pate4^-, Pate4^{tm1a(KOMP)Osb}
• Gene: Pate4 Location: Chr9:35518387-35523164 bp, - strand Genetic Position: Chr9, 20.34 cM, cytoband A5.3
• Alliance: Pate4^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276935
• Parent Cell Line: EGR-G101 (ES Cell)
• Strain of Origin: C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Targeting vector DPGS00175_A_E06 from the International Mouse Phenotyping Consortium (IKMC Project ID: #36005) was used to generate the allele. Exon 2 was replaced with an FRT-lacZ-loxP-neo-FRT-loxP containing cassette. Western blot analysis confirmed the absence of protein expression in the seminal vesicles of homozygous mutant mice. (J:276935)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pate4 Mutation: 24 strains or lines available

References

• Original: J:276935 Noda T, et al., Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity. Biol Reprod. 2019 Apr 1;100(4):1035-1045
• All: 1 reference(s)