Tg(Thy1-APP*Swe*Ind)fAccu
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP*Swe*Ind)fAccu
• Name: transgene insertion f, A Claudio Cuello
• MGI ID: MGI:6324681
• Synonyms: McGill-Thy1-APP Tg
• Transgene: Tg(Thy1-APP*Swe*Ind)fAccu Location: unknown
• Alliance: Tg(Thy1-APP*Swe*Ind)fAccu page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP*Swe*Ind)fAccu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  Contains the Swedish double mutation K670N and M671L and the Indiana mutation V717F

• Mutation details: The murine thymocyte antigen promotor (Thy1) drives the expression of the human APP (APP-751) cDNA bearing the Swedish double mutation K670N and M671L and the Indiana mutation V717F primarily in pyramidal neurons of the telencephalon and starting postnatally. Transgene copy number as assessed by Southern blotting is estimated to be about 20. Western blot analysis confirmed overexpression of the transgene in the hippocampus and cortex. Mice express on average 2-fold higher levels of amyloid beta42 than of amyloid beta40 in both cortex and hippocampus. (J:251735)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:251735 Ferretti MT, et al., Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res. 2011 Feb;8(1):4-23
• All: 4 reference(s)