Tg(Thy1-DCTN1*G71A)#Ytsu
Transgene Detail

Summary

• Symbol: Tg(Thy1-DCTN1*G71A)#Ytsu
• Name: transgene insertion, Yoshio Tsuboi
• MGI ID: MGI:6331092
• Synonyms: DCTN1^G71A
• Transgene: Tg(Thy1-DCTN1*G71A)#Ytsu Location: unknown
• Alliance: Tg(Thy1-DCTN1*G71A)#Ytsu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-DCTN1*G71A)#Ytsu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DCTN1 (1639)

  Dctn1

  (MGI:107745)

  Contains a G71A mutation found in Perry Syndrome patients

• Mutation details: The mouse Thy1 promoter drives the expression of a C-terminally FLAG-tagged human dynactin 1 cDNA with a G71A missense mutation. This is a mutation found in patients with Perry Syndrome. One line showing high expression in the central nervous system was established, however the pound (#) sign is used as line number is not specified. (J:258003)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:258003 Mishima T, et al., Behavioral defects in a DCTN1(G71A) transgenic mouse model of Perry syndrome. Neurosci Lett. 2018 Feb 14;666:98-103
• All: 1 reference(s)