Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz
Transgene Detail

Summary

• Symbol: Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz
• Name: transgene insertion, Katalin Susztak
• MGI ID: MGI:6331299
• Synonyms: TRE-APOL1-G1
• Transgene: Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz Location: unknown
• Alliance: Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The human APOL1 kidney disease risk variant G1 contains a double missense mutation resulting in a serine to glycine change at amino acid 342 (S342G) and isoleucine to methionine change at amino acid 384 (I384M) and is able to lyse T. brucei rhodesiense, is under the control of the tetracycline responsive promoter element. The pound (#) sign is used when the line number is not specified or lines are pooled. The gene is only expressed in a tetracycline/doxycycline controllable manner when mice carrying this allele also carry a tTA or rtTA allele. (J:251848)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:251848 Beckerman P, et al., Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017 Apr;23(4):429-438
• All: 1 reference(s)