P2rx2^{tm1.1(cre)Ttc}
Targeted Allele Detail

Summary

• Symbol: P2rx2^{tm1.1(cre)Ttc}
• Name: purinergic receptor P2X, ligand-gated ion channel, 2; targeted mutation 1, Thomas E Taylor-Clark
• MGI ID: MGI:6331316
• Gene: P2rx2 Location: Chr5:110487678-110491078 bp, - strand Genetic Position: Chr5, 53.49 cM
• Alliance: P2rx2^{tm1.1(cre)Ttc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290412
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• P2rx2^{tm1.1(cre)Ttc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	P2rx2 (MGI:2665170)

• Mutation details: The targeting vector using bacterial artificial chromosomes (BACs) clone RP23-333M22 and RP23-354O18 was constructed by inserting a 2A-Cre cassette to replace the TGA stop codon of the P2rx2 gene. The Neo cassette flanked by SDA (self-deletion anchor) sites were removed in the cell. The vector was transfected into the C57BL/6 ES cell to establish mouse line by homologous recombination. (J:290412)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	P2rx2 (mouse) Summary of all recombinase alleles driven by P2rx2. Comparative matrix view of recombinase activities Alliance mouse P2rx2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2rx2 Mutation: 31 strains or lines available

References

• Original: J:290412 Kim SH, et al., Development of a mouse reporter strain for the purinergic P2X2 receptor. eNeuro. 2020 Jul 15;:ENEURO.0203-20.2020
• All: 2 reference(s)