Cfap144^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Cfap144^tm1.2Arte
• Name: cilia and flagella associated protein 144; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:6336088
• Synonyms: Fam183b^deltaex1
• Gene: Cfap144 Location: Chr11:58683628-58692786 bp, - strand Genetic Position: Chr11, 36.3 cM, cytoband B2
• Alliance: Cfap144^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277272
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and approximately 1.5 kb of sequence upstream of exon 1 (promotor region) was flanked by loxP sites. A FRT-flanked puromycin resistance gene was inserted into intron 1 and removed via Flp-mediated recombination. Cre-mediated recombination removed the floxed region deleting the promotor region and transcriptional and translational start sites. Western blot analysis of testis lysates confirmed absence of protein in homozygotes. (J:277272)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfap144 Mutation: 5 strains or lines available

References

• Original: J:277272 Beckers A, et al., The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Sci Rep. 2018 Oct 2;8(1):14678
• All: 1 reference(s)