Lrrn3^{em1(IMPC)Kmpc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrn3^{em1(IMPC)Kmpc}
• Name: leucine rich repeat protein 3, neuronal; endonuclease-mediated mutation 1, Korea Mouse Phenotyping Center
• MGI ID: MGI:6336123
• Gene: Lrrn3 Location: Chr12:41501667-41536056 bp, - strand Genetic Position: Chr12, 18.94 cM, cytoband B3
• Alliance: Lrrn3^{em1(IMPC)Kmpc} page
• IMPC: Lrrn3 gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele from IMPC was generated at Korea Mouse Phenotype Consortium by injecting CAS9 RNA and 2 guide sequences CCGGCAGCTCAGTTAGCTTGTTT, TCTCACAGGTACATAATTGGGGG, which resulted in a Indel. (J:237616)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Lrrn3^em1(IMPC)Kmpc/Lrrn3^em1(IMPC)Kmpc	C57BL/6NTac-Lrrn3^em1(IMPC)Kmpc/Kmpc

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - KMPC
skeleton	√
decreased bone mineral content	√
decreased bone mineral density	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrn3 Mutation: 33 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 2 reference(s)