Gja8^Aey69
Chemically induced Allele Detail

Summary

• Symbol: Gja8^Aey69
• Name: gap junction protein, alpha 8; abnormal eyes 69
• MGI ID: MGI:6342052
• Gene: Gja8 Location: Chr3:96820882-96833336 bp, - strand
• Alliance: Gja8^Aey69 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU treatment caused an T>C mutation in the coding region (c.71T>C) that leads to to the change of valine codon 24 to alanine (p.Val24Ala). This mutation is linked to H3c14 and the two mutations are found in mice with a dominant small-eye phenotype (microphthalmia without a lens but with retinal hyperproliferation). (J:277247)

Expression

In Mice Carrying this Mutation:

93 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja8 Mutation: 33 strains or lines available

References

• Original: J:277247 Vetrivel S, et al., Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019 Apr 13
• All: 1 reference(s)