Ipo4^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ipo4^em1(IMPC)J
• Name: importin 4; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6342428
• Gene: Ipo4 Location: Chr14:55862857-55873321 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ipo4^em1(IMPC)J page
• IMPC: Ipo4 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TGAATGGTTCTGGTTTGCCG and ATAAGACCACCGACAGCTGG, which resulted in a 1170 bp deletion beginning at Chromosome 14 position 55,632,815 bp and ending after 55,634,584 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001294570 through ENSMUSE00001229180 (exons 5-10) and 1043 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 93 and early truncation 17 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ipo4 Mutation: 39 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)