Myo18a^{tm1d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Myo18a^{tm1d(KOMP)Wtsi}
• Name: myosin XVIIIA; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:6342448
• Gene: Myo18a Location: Chr11:77654072-77756806 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Myo18a^{tm1d(KOMP)Wtsi} page
• IMPC: Myo18a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277320
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre excision of the tm1c allele removes the lacZ/neo cassette and the loxP-flanked exons. (J:277320)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo18a Mutation: 124 strains or lines available

References

• Original: J:277320 Horsthemke M, et al., A novel isoform of myosin 18A (Myo18Agamma) is an essential sarcomeric protein in mouse heart. J Biol Chem. 2019 May 3;294(18):7202-7218
• All: 1 reference(s)