Ccnt1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccnt1^em1(IMPC)J
• Name: cyclin T1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6342504
• Gene: Ccnt1 Location: Chr15:98436570-98468340 bp, - strand Genetic Position: Chr15, 54.54 cM, cytoband F2
• Alliance: Ccnt1^em1(IMPC)J page
• IMPC: Ccnt1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TCCTGGGTAAAAATGTCTGT and AGTTATTTACATCCTTTTGC, which resulted in a 231 bp deletion beginning at Chromosome 15 position 98,554,468 bp and ending after 98,554,698 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001268103 (exon 4) and 170 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 124 and early truncation 3 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccnt1 Mutation: 41 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)