Rit1^tm1.1Tumg
Targeted Allele Detail

Summary

• Symbol: Rit1^tm1.1Tumg
• Name: Ras-like without CAAX 1; targeted mutation 1.1, Yoko Aoki
• MGI ID: MGI:6342637
• Synonyms: Rit1^A57G
• Gene: Rit1 Location: Chr3:88624154-88638354 bp, + strand Genetic Position: Chr3, 38.95 cM, cytoband F1
• Alliance: Rit1^tm1.1Tumg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277548
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: An alanine to glycine mutation at amino acid 57 (A57G) was introduced in exon 4 and an SA-STOP-SV40polyA-FRT-neomycin cassette flanked by loxP sites was inserted in the intron upstream of the mutation. Cre-mediated recombination removed the STOP/selection cassette. (J:277548)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rit1 Mutation: 18 strains or lines available

References

• Original: J:277548 Takahara S, et al., New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to beta-adrenergic stimulation-induced cardiac fibrosis. EBioMedicine. 2019 Apr;42:43-53
• All: 1 reference(s)