Cog1^em1(IMPC)Bay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cog1^em1(IMPC)Bay
• Name: component of oligomeric golgi complex 1; endonuclease-mediated mutation 1, Baylor College of Medicine
• MGI ID: MGI:6342908
• Synonyms: Cog1^-
• Gene: Cog1 Location: Chr11:113539995-113557880 bp, + strand Genetic Position: Chr11, 79.1 cM, cytoband E2
• Alliance: Cog1^em1(IMPC)Bay page
• IMPC: Cog1 gene page

Cog1^em1(IMPC)Bay/Cog1^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths with a poorly defined inner cell mass after 3 days in culture.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at Bayor College of Medicine by injecting CAS9 Protein and 4 guide sequences CCCCAGGCCTGTGTAAACGGAGC, TGTGCATAGCACAGCTTAGCTGG, CTGGCAATAAACCAGTGAACCGG, CCACACACGGAAAAGCTTGAGAT, which resulted in a Exon Deletion. (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cog1 Mutation: 35 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 4 reference(s)