Ankrd31em1Atot
Endonuclease-mediated Allele Detail
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Symbol: |
Ankrd31em1Atot |
Name: |
ankyrin repeat domain 31; endonuclease-mediated mutation 1, Attila Toth |
MGI ID: |
MGI:6343192 |
Synonyms: |
Ankrd31-, Ankrd31mut1, mut1 |
Gene: |
Ankrd31 Location: Chr13:96884797-97046302 bp, + strand Genetic Position: Chr13, Syntenic
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Alliance: |
Ankrd31em1Atot page
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Strain of Origin: |
Not Specified
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: CRIPSR/Cas9 genome editing created a 5 bp deletion as well as an insertion of four A residues in exon 6. This results in a frameshift after the 134th codon in the longest open reading frame, and is predicted to severely truncate the encoded protein. Immunoprecipitation-Western blot analysis of testis extracts and immunofluorescence in fixed gonadal samples confirmed that domains that are C-terminal to the frameshift position are not produced in homozygous mutant meiocytes.
(J:276412)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ankrd31 Mutation: |
39 strains or lines available
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Original: |
J:276412 Papanikos F, et al., Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Mol Cell. 2019 Jun 6;74(5):1069-1085.e11 |
All: |
1 reference(s) |
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