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Ankrd31em1Atot
Endonuclease-mediated Allele Detail
Summary
Symbol: Ankrd31em1Atot
Name: ankyrin repeat domain 31; endonuclease-mediated mutation 1, Attila Toth
MGI ID: MGI:6343192
Synonyms: Ankrd31-, Ankrd31mut1, mut1
Gene: Ankrd31  Location: Chr13:96884797-97046302 bp, + strand  Genetic Position: Chr13, Syntenic
Alliance: Ankrd31em1Atot page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCRIPSR/Cas9 genome editing created a 5 bp deletion as well as an insertion of four A residues in exon 6. This results in a frameshift after the 134th codon in the longest open reading frame, and is predicted to severely truncate the encoded protein. Immunoprecipitation-Western blot analysis of testis extracts and immunofluorescence in fixed gonadal samples confirmed that domains that are C-terminal to the frameshift position are not produced in homozygous mutant meiocytes. (J:276412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ankrd31 Mutation:  39 strains or lines available
References
Original:  J:276412 Papanikos F, et al., Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Mol Cell. 2019 Jun 6;74(5):1069-1085.e11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory