Ythdf3^em1Caox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ythdf3^em1Caox
• Name: YTH N6-methyladenosine RNA binding protein 3; endonuclease-mediated mutation 1, Xuetao Cao
• MGI ID: MGI:6343198
• Synonyms: YTHDF3^-
• Gene: Ythdf3 Location: Chr3:16237376-16271201 bp, + strand Genetic Position: Chr3, 4.04 cM
• Alliance: Ythdf3^em1Caox page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/Cas9 genome editing technology was used to delete exon 4. Immunoblot analysis confirmed the absence of protein expression in bone marrow-derived macrophages (BMDMs) from homozygous mutant mice. (J:276397)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ythdf3 Mutation: 55 strains or lines available

References

• Original: J:276397 Zhang Y, et al., RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):976-981
• All: 1 reference(s)