Plekhf1^tm1.1Caox
Targeted Allele Detail

Summary

• Symbol: Plekhf1^tm1.1Caox
• Name: pleckstrin homology domain containing, family F (with FYVE domain) member 1; targeted mutation 1.1, Xuetao Cao
• MGI ID: MGI:6343232
• Synonyms: Lapf^fl
• Gene: Plekhf1 Location: Chr7:37920078-37927418 bp, - strand Genetic Position: Chr7, 25.36 cM, cytoband B1
• Alliance: Plekhf1^tm1.1Caox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277440
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2. An FRT-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:277440)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekhf1 Mutation: 18 strains or lines available

References

• Original: J:277440 Li T, et al., An endosomal LAPF is required for macrophage endocytosis and elimination of bacteria. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12958-12963
• All: 1 reference(s)