Fbxw11^tm1Nakay
Targeted Allele Detail

Summary

• Symbol: Fbxw11^tm1Nakay
• Name: F-box and WD-40 domain protein 11; targeted mutation 1, Keiko Nakayama
• MGI ID: MGI:6343251
• Synonyms: beta-TrCP2^-
• Gene: Fbxw11 Location: Chr11:32592724-32696816 bp, + strand Genetic Position: Chr11, 19.02 cM
• Alliance: Fbxw11^tm1Nakay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228222
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6 were replaced with a neomycin selection cassette. RT-qPCR analysis confirmed the absence of mRNA expression in E9.5 homozygous mutant embryos. (J:228222)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw11 Mutation: 72 strains or lines available

References

• Original: J:228222 Nakagawa T, et al., S6 Kinase- and beta-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation. Mol Cell Biol. 2015 Oct;35(20):3517-27
• All: 3 reference(s)