Sec31a^em1H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sec31a^em1H
• Name: SEC31 homolog A, COPII coat complex component; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:6343337
• Gene: Sec31a Location: Chr5:100509508-100564093 bp, - strand Genetic Position: Chr5, 48.48 cM, cytoband E3
• Alliance: Sec31a^em1H page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated in C57BL/6J via CRISPR/Cas9 and guide sequences and has a 1055 nt deletion encompassing exon 21 to induce a premature stop codon and a null allele. (J:351615)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec31a Mutation: 70 strains or lines available

References

• Original: J:351615 Tobias ES, et al., SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine. 2024 May;84(2):345-349
• All: 1 reference(s)