Ccdc63^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc63^em1Osb
• Name: coiled-coil domain containing 63; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6343353
• Synonyms: Ccdc63⁺¹
• Gene: Ccdc63 Location: Chr5:122246115-122276143 bp, - strand Genetic Position: Chr5, 62.17 cM
• Alliance: Ccdc63^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 mutagenesis introduced a 1 bp G insertion in exon 4. This insertion resulted in a frameshift mutation at codon E38G with a premature stop codon introduced 53 amino acids later. (J:231237)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccdc63 Mutation: 32 strains or lines available

References

• Original: J:231237 Young SA, et al., CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Int J Mol Sci. 2015;16(10):24732-50
• All: 1 reference(s)