Arhgap31^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Arhgap31^tm1.1Itl
• Name: Rho GTPase activating protein 31; targeted mutation 1.1 InGenious Targeting Laboratory
• MGI ID: MGI:6343384
• Synonyms: CdGAP^fl
• Gene: Arhgap31 Location: Chr16:38418705-38533397 bp, - strand Genetic Position: Chr16, 26.87 cM, cytoband B4
• Alliance: Arhgap31^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253757
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A single loxP site containing an engineered EcoRV sequence was inserted 177bp 5' of exon 1, and a loxP/FRT flanked Neo cassette containing an engineered Spe1 sequence was inserted 270bp 3' of exon 1. The Neo cassette was removed via FLP-mediated recombination. (J:253757)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap31 Mutation: 38 strains or lines available

References

• Original: J:253757 Caron C, et al., CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis. Sci Rep. 2016 Jun 7;6:27485
• All: 3 reference(s)