Klhdc10^tm1Hijo
Targeted Allele Detail

Summary

• Symbol: Klhdc10^tm1Hijo
• Name: kelch domain containing 10; targeted mutation 1, Hidenori Ichijo
• MGI ID: MGI:6343386
• Gene: Klhdc10 Location: Chr6:30401867-30455178 bp, + strand Genetic Position: Chr6, 12.52 cM, cytoband A3
• Alliance: Klhdc10^tm1Hijo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251158
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette. Immunoblot analysis confirmed the absence of protein expression in primary mouse embryonic fibroblasts (MEFs) derived from homozygous mutant mice. (J:251158)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klhdc10 Mutation: 32 strains or lines available

References

• Original: J:251158 Yamaguchi N, et al., KLHDC10 Deficiency Protects Mice against TNFalpha-Induced Systemic Inflammation. PLoS One. 2016;11(9):e0163118
• All: 1 reference(s)