Prss34^tm1.1Hkar
Targeted Allele Detail

Summary

• Symbol: Prss34^tm1.1Hkar
• Name: serine protease 34; targeted mutation 1, Hajime Karasuyama
• MGI ID: MGI:6343399
• Synonyms: Mcpt11^-, mMCP-11 deficient
• Gene: Prss34 Location: Chr17:25517368-25519142 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Prss34^tm1.1Hkar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238924
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 - 3 were replaced with a loxP-flanked neomycin selection cassette. The neomycin selection cassette was removed via Cre-mediated recombination. Western blot analysis confirmed the absence of protein expression in bone marrow-derived basophils (BMBAs) generated from homozygous mutant mice. (J:238924)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss34 Mutation: 9 strains or lines available

References

• Original: J:238924 Iki M, et al., Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016 Dec 22;128(25):2909-2918
• All: 1 reference(s)