Ttll9^tm1Seto
Targeted Allele Detail

Summary

• Symbol: Ttll9^tm1Seto
• Name: tubulin tyrosine ligase-like family, member 9; targeted mutation 1, Mitsutoshi Setou
• MGI ID: MGI:6343411
• Synonyms: Ttll9^-
• Gene: Ttll9 Location: Chr2:152804405-152850402 bp, + strand Genetic Position: Chr2, 75.41 cM, cytoband H2
• Alliance: Ttll9^tm1Seto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246509
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5, which contain the initial part of the TTL domain essential for polyglutamylase activity, were replaced with a neomycin selection cassette. A stop codon introduced by a frameshift resulted in premature termination of translation. (J:246509)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ttll9 Mutation: 42 strains or lines available

References

• Original: J:246509 Konno A, et al., Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating. J Cell Sci. 2016 Jul 15;129(14):2757-66
• All: 1 reference(s)