Pdgfd^tm1Ueks
Targeted Allele Detail

Summary

• Symbol: Pdgfd^tm1Ueks
• Name: platelet-derived growth factor, D polypeptide; targeted mutation 1, Ulf Eriksson
• MGI ID: MGI:6343510
• Synonyms: Pdgf^-
• Gene: Pdgfd Location: Chr9:6168584-6378850 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Pdgfd^tm1Ueks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249014
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 0.1 kb from the ATG start codon to the 3'-end of exon 1 was replaced by a LacZ reporter gene cassette and a neomycin resistance cassette flanked by two LoxP sites. qPCR analysis confirmed the absence of mRNA expression in cardiac tissue from homozygous mutant mice. (J:249014)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfd Mutation: 33 strains or lines available

References

• Original: J:249014 Gladh H, et al., Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype. PLoS One. 2016;11(3):e0152276
• All: 3 reference(s)