Il17rb^{tm1.1(cre/ERT2)Seno}
Targeted Allele Detail

Summary

• Symbol: Il17rb^{tm1.1(cre/ERT2)Seno}
• Name: interleukin 17 receptor B; targeted mutation 1.1, Hiroshi Seno
• MGI ID: MGI:6343524
• Synonyms: Il17rb-CreERT2-IRES-EGFP
• Gene: Il17rb Location: Chr14:29718125-29730853 bp, - strand Genetic Position: Chr14, 18.39 cM
• Alliance: Il17rb^{tm1.1(cre/ERT2)Seno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277412
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Il17rb^{tm1.1(cre/ERT2)Seno} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il17rb (MGI:1355292)

• Mutation details: Homologous recombination was employed to insert a cre/ERT2-IRES-EGFP-polyA-Frt-neo-Frt cassette into the Il17rb gene immediately after the ATG start codon in exon 1. After germline transmission was established, the neo cassette was excised in vivo by crossing mutants to Flp-expressing mice. (J:277412)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il17rb (mouse) Summary of all recombinase alleles driven by Il17rb. Alliance mouse Il17rb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17rb Mutation: 42 strains or lines available

References

• Original: J:277412 Goto N, et al., Lineage tracing and targeting of IL17RB(+) tuft cell-like human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12996-13005
• All: 1 reference(s)