Agpat1^tm1Garg
Targeted Allele Detail

Summary

• Symbol: Agpat1^tm1Garg
• Name: 1-acylglycerol-3-phosphate O-acyltransferase 1; targeted mutation 1, Abhimanyu Garg
• MGI ID: MGI:6343539
• Synonyms: Agpat1^-
• Gene: Agpat1 Location: Chr17:34823236-34832423 bp, + strand Genetic Position: Chr17, 18.18 cM
• Alliance: Agpat1^tm1Garg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250301
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All coding exons (exons 2-7) were replaced with a lacZ and neomycin selection cassette. Real-time quantitative PCR analysis confirmed the absence of mRNA expression in the liver, testis, epididymal white adipose tissue (eWAT), and brown adipose tissue (BAT) of homozygous mutant mice. (J:250301)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agpat1 Mutation: 10 strains or lines available

References

• Original: J:250301 Agarwal AK, et al., Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice. Endocrinology. 2017 Nov 01;158(11):3954-3973
• All: 1 reference(s)