Vgll2^tm1Tm
Targeted Allele Detail

Summary

• Symbol: Vgll2^tm1Tm
• Name: vestigial like family member 2; targeted mutation 1, Takayuki Morisaki
• MGI ID: MGI:6343554
• Gene: Vgll2 Location: Chr10:51898598-51904567 bp, + strand Genetic Position: Chr10, 26.16 cM
• Alliance: Vgll2^tm1Tm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258195
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ expression cassette with a SV40 polyadenylation signal, which was followed by a loxP-flanked puromycin resistant gene expression cassette (Puro) in the reverse orientation, was fused to the initiation codon of the gene. (J:258195)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Vgll2^tm1Tm/Vgll2^tm1Tm	involves: 129S2/SvPas * C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
behavior/neurological	√
impaired exercise endurance	√
homeostasis/metabolism	√
impaired exercise endurance	√
muscle	√
abnormal skeletal muscle fiber type ratio	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vgll2 Mutation: 14 strains or lines available

References

• Original: J:258195 Honda M, et al., Vestigial-like 2 contributes to normal muscle fiber type distribution in mice. Sci Rep. 2017 Aug 2;7(1):7168
• All: 2 reference(s)