Rnf186^tm1Ktak
Targeted Allele Detail

Summary

• Symbol: Rnf186^tm1Ktak
• Name: ring finger protein 186; targeted mutation 1, Kiyoshi Takeda
• MGI ID: MGI:6343556
• Synonyms: Rnf186^-
• Gene: Rnf186 Location: Chr4:138694430-138695676 bp, + strand Genetic Position: Chr4, 70.57 cM, cytoband D3
• Alliance: Rnf186^tm1Ktak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258197
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.8-Kb fragment encoding the exon region was replaced with a neomycin-resistant gene cassette. Quantitative RT-PCR analysis confirmed the absence of mRNA expression in various gastrointestinal tissues (stomach, duodenum, jejunum, ileum, cecum, and colon) as well as in colonic epithelial cells of homozygous mutant mice. (J:258197)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf186 Mutation: 11 strains or lines available

References

• Original: J:258197 Fujimoto K, et al., Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 2017 Mar;10(2):446-459
• All: 1 reference(s)