Rnf186^em1Ktak
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf186^em1Ktak
• Name: ring finger protein 186; endonuclease-mediated mutation 1, Kiyoshi Takeda
• MGI ID: MGI:6343557
• Synonyms: Rnf186^A117T
• Gene: Rnf186 Location: Chr4:138694430-138695676 bp, + strand Genetic Position: Chr4, 70.57 cM, cytoband D3
• Alliance: Rnf186^em1Ktak page

Mutation origin

• Strain of Origin: B6D2F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: The codon for alanine at the 117th position (corresponding to the 64th position in human RNF186) was substituted with a codon encoding threonine using the CRISPR/Cas9 system. (J:258197)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf186 Mutation: 11 strains or lines available

References

• Original: J:258197 Fujimoto K, et al., Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 2017 Mar;10(2):446-459
• All: 1 reference(s)