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Stx4atm1.2Radac
Targeted Allele Detail
Summary
Symbol: Stx4atm1.2Radac
Name: syntaxin 4A (placental); targeted mutation 1.2, Roberto Adachi
MGI ID: MGI:6355366
Synonyms: Stx4-
Gene: Stx4a  Location: Chr7:127439832-127450160 bp, + strand  Genetic Position: Chr7, 69.77 cM, cytoband F4
Alliance: Stx4atm1.2Radac page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:275367
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 (GRCm38; Chr7:127841278) and a second loxP site, followed by the phosphoglucokinase promoter-driven neomycin resistance gene (PGK-Neo) flanked by two FRT sites, was introduced in intron 4 (GRCm38; Chr7:127842997). The neomycin selection cassette was removed via Flp-mediated recombination, leaving exons 1-4 floxed. Subsequent Cre expression in the germline resulted in the deletion of the loxP-flanked genomic sequences, generating a knockout allele. (J:275367)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stx4a Mutation:  22 strains or lines available
References
Original:  J:275367 Sanchez E, et al., Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis. J Biol Chem. 2019 Mar 1;294(9):3012-3023
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory