Stx4atm1.2Radac
Targeted Allele Detail
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Symbol: |
Stx4atm1.2Radac |
Name: |
syntaxin 4A (placental); targeted mutation 1.2, Roberto Adachi |
MGI ID: |
MGI:6355366 |
Synonyms: |
Stx4- |
Gene: |
Stx4a Location: Chr7:127439832-127450160 bp, + strand Genetic Position: Chr7, 69.77 cM, cytoband F4
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Alliance: |
Stx4atm1.2Radac page
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Germline Transmission: |
Earliest citation of germline transmission:
J:275367
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 1 (GRCm38; Chr7:127841278) and a second loxP site, followed by the phosphoglucokinase promoter-driven neomycin resistance gene (PGK-Neo) flanked by two FRT sites, was introduced in intron 4 (GRCm38; Chr7:127842997). The neomycin selection cassette was removed via Flp-mediated recombination, leaving exons 1-4 floxed. Subsequent Cre expression in the germline resulted in the deletion of the loxP-flanked genomic sequences, generating a knockout allele.
(J:275367)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Stx4a Mutation: |
22 strains or lines available
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Original: |
J:275367 Sanchez E, et al., Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis. J Biol Chem. 2019 Mar 1;294(9):3012-3023 |
All: |
1 reference(s) |
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