Dlk2^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Dlk2^tm1.1Geno
• Name: delta like non-canonical Notch ligand 2; targeted mutation 1.1, Genoway
• MGI ID: MGI:6355376
• Synonyms: Dlk2^-
• Gene: Dlk2 Location: Chr17:46608347-46614197 bp, + strand Genetic Position: Chr17, 22.9 cM
• Alliance: Dlk2^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272796
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single distal loxP site was inserted within intron 1 and a loxP site together with an FRT-flanked neomycin selection cassette was inserted in intron 4. Cre-mediated recombination of the loxP sites surrounding exons 2-4 in the germline resulted in deletion of the loxP flanked sequences. (J:272796)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Dlk2^tm1.1Geno/Dlk2^tm1.1Geno	involves: 129P2/OlaHsd * C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
behavior/neurological	√
behavior/neurological phenotype	N
impaired behavioral response to xenobiotic	√
increased depression-related behavior	√
increased anxiety-related response	√
nervous system	√
abnormal nervous system physiology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlk2 Mutation: 13 strains or lines available

References

• Original: J:272796 Navarrete F, et al., Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam. Psychoneuroendocrinology. 2017 Nov;85:134-141
• All: 1 reference(s)