Orc1^tm1.1Gle
Targeted Allele Detail

Summary

• Symbol: Orc1^tm1.1Gle
• Name: origin recognition complex, subunit 1; targeted mutation 1.1, Gustavo Leone
• MGI ID: MGI:6355393
• Synonyms: Orc1^f
• Gene: Orc1 Location: Chr4:108436651-108472030 bp, + strand Genetic Position: Chr4, 50.64 cM, cytoband D
• Alliance: Orc1^tm1.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272584
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 9. An FRT-flanked neomycin selection cassette with a 3' loxP site was inserted downstream of exon 14. Flp-mediated recombination removed the neomycin selection cassette and left exons 9-14 floxed. (J:272584)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Orc1 Mutation: 60 strains or lines available

References

• Original: J:272584 Okano-Uchida T, et al., Endoreduplication of the mouse genome in the absence of ORC1. Genes Dev. 2018 Jul 1;32(13-14):978-990
• All: 1 reference(s)