Zic2^iso
Chemically induced Allele Detail

Summary

• Symbol: Zic2^iso
• Name: zinc finger protein of the cerebellum 2; isomeric
• MGI ID: MGI:6355448
• Gene: Zic2 Location: Chr14:122712847-122717264 bp, + strand Genetic Position: Chr14, 65.97 cM
• Alliance: Zic2^iso page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: The ENU-induced mutation is a C to A alteration that results in a stop-gain mutation of tyrosine 401 (p.Y401*) in the encoded protein. This disrupts the fifth zinc finger domain of the protein. (J:268103)

Expression

In Mice Carrying this Mutation:	45 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zic2 Mutation: 41 strains or lines available

References

• Original: J:268103 Dykes IM, et al., A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Sci Rep. 2018 Jul 11;8(1):10439
• All: 1 reference(s)