Otp^M1H
Chemically induced Allele Detail

Summary

• Symbol: Otp^M1H
• Name: orthopedia homeobox; mutation 1, Harwell
• MGI ID: MGI:6355465
• Synonyms: Otp1^R108W
• Gene: Otp Location: Chr13:95012144-95021633 bp, + strand Genetic Position: Chr13, 49.22 cM
• Alliance: Otp^M1H page

Mutation origin

• Strain of Origin: (C3H/HeH x C57BL/6J)F1

Mutation description

• Allele Type: Chemically induced (ENU) (Dominant negative)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is at base 490 in ENSMUST00000022195.11, which was mutated from a C to a T in the F1 founder, resulting in a missense amino acid substitution at residue 108, arginine (R) to tryptophan (W), p.R108W. (J:251771)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otp Mutation: 17 strains or lines available

References

• Original: J:251771 Moir L, et al., Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety. Mol Metab. 2017 Nov;6(11):1419-1428
• All: 1 reference(s)