Cnpy2^tm1.2Zhli
Targeted Allele Detail

Summary

• Symbol: Cnpy2^tm1.2Zhli
• Name: canopy FGF signaling regulator 2; targeted mutation 1.2 Zihai Li
• MGI ID: MGI:6355915
• Synonyms: Cnpy2^-
• Gene: Cnpy2 Location: Chr10:128157972-128163056 bp, + strand Genetic Position: Chr10, 76.52 cM
• Alliance: Cnpy2^tm1.2Zhli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2-5 were deleted via Cre-mediated recombination of flanking loxP sites in the germline. Immunoblotting confirmed the absence of protein expression in kidney and liver tissues of homozygous mutant mice. (J:277868)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnpy2 Mutation: 31 strains or lines available

References

• Original: J:277868 Hong F, et al., CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. Nat Struct Mol Biol. 2017 Oct;24(10):834-839
• All: 1 reference(s)