Ggnbp2^tm1Bbs
Targeted Allele Detail

Summary

• Symbol: Ggnbp2^tm1Bbs
• Name: gametogenetin binding protein 2; targeted mutation 2, Beate Brand-Saberi
• MGI ID: MGI:6355945
• Gene: Ggnbp2 Location: Chr11:84723187-84761643 bp, - strand Genetic Position: Chr11, 51.34 cM
• Alliance: Ggnbp2^tm1Bbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270533
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 to 7 (6159bp, from bp 27252 to bp 33409 of ENSMUST00000100685) were replaced with an FRT-flanked neomycin selection cassette. The insertion results in the destruction of all potential open reading frames of the encoded protein isoforms. (J:270533)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggnbp2 Mutation: 61 strains or lines available

References

• Original: J:270533 Chen A, et al., GGNBP2 is necessary for testis morphology and sperm development. Sci Rep. 2017 Jun 7;7(1):2998
• All: 1 reference(s)