Ythdf1^em1Chhe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ythdf1^em1Chhe
• Name: YTH N6-methyladenosine RNA binding protein 1; endonuclease-mediated mutation 1, Chuan He
• MGI ID: MGI:6356299
• Synonyms: Ythdf1-KO
• Gene: Ythdf1 Location: Chr2:180546170-180562729 bp, - strand Genetic Position: Chr2, 103.5 cM
• Alliance: Ythdf1^em1Chhe page

Mutation origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mutagenesis induced deletion mutations in exon 4. Founder #4 with a 179-bp deletion was selected for further analysis. Complete elimination of encoded protein was verified in the hippocampus and other brain regions by Western blot analysis. (J:267186)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ythdf1 Mutation: 37 strains or lines available

References

• Original: J:267186 Shi H, et al., m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature. 2018 Nov;563(7730):249-253
• All: 8 reference(s)