Efcab9^em2Chng
Endonuclease-mediated Allele Detail

Summary

• Symbol: Efcab9^em2Chng
• Name: EF-hand calcium binding domain 9; endonuclease-mediated mutation 2, Jean-Ju Chung
• MGI ID: MGI:6356321
• Synonyms: Mut (5del)
• Gene: Efcab9 Location: Chr11:32472751-32482081 bp, - strand Genetic Position: Chr11, 18.97 cM, cytoband A5
• Alliance: Efcab9^em2Chng page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mutagenesis induced a 5 bp deletion in exon 1. This results in a frameshift and early termination of translation. (J:276402)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efcab9 Mutation: 12 strains or lines available

References

• Original: J:276402 Hwang JY, et al., Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Cell. 2019 May 30;177(6):1480-1494.e19
• All: 1 reference(s)