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Sun5em1Wli
Endonuclease-mediated Allele Detail
Summary
Symbol: Sun5em1Wli
Name: Sad1 and UNC84 domain containing 5; endonuclease-mediated mutation 1, Wei Li
MGI ID: MGI:6356352
Synonyms: Sun5-13bp
Gene: Sun5  Location: Chr2:153698108-153713004 bp, - strand  Genetic Position: Chr2, 75.99 cM, cytoband H2
Alliance: Sun5em1Wli page
Mutation
origin
Strain of Origin:  B6D2F1
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 mutagenesis induced a 13bp deletion of TGACCGCGGCCAG (reverse strand) in exon 10, causing a frameshift and premature stop codon. (J:247612)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6J * DBA/2
 
Sun5em1Wli/Sun5+
involves: C57BL/6J * DBA/2
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
cellular
teratozoospermia
abnormal sperm axoneme morphology
abnormal sperm connecting piece morphology
abnormal sperm head morphology
globozoospermia
absent sperm head
mortality/aging
N N N N
mortality/aging
N N N N
reproductive system
N
reproductive system phenotype
N N
teratozoospermia
abnormal sperm axoneme morphology
abnormal sperm connecting piece morphology
abnormal sperm head morphology
globozoospermia
absent sperm head
abnormal spermiation
male infertility
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sun5 Mutation:  18 strains or lines available
References
Original:  J:247612 Shang Y, et al., Essential role for SUN5 in anchoring sperm head to the tail. Elife. 2017 Sep 25;6:e28199
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory