Chd9^em2Ibbr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chd9^em2Ibbr
• Name: chromodomain helicase DNA binding protein 9; endonuclease-mediated mutation 2, Fugaku Aoki
• MGI ID: MGI:6356369
• Synonyms: KO#2
• Gene: Chd9 Location: Chr8:91554980-91781144 bp, + strand Genetic Position: Chr8, 44.25 cM
• Alliance: Chd9^em2Ibbr page

Mutation origin

• Strain of Origin: C57BL/6NCrSlc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1 bp deletion within the Chd9 open reading frame causing a frameshift. The mutant mouse is predicted to express a 356 amino acid polypeptide, in contrast to the 2869 amino acid native polypeptide. (J:270181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chd9 Mutation: 250 strains or lines available

References

• Original: J:270181 Ooga M, et al., Chd9 mediates highly loosened chromatin structure in growing mouse oocytes. Biochem Biophys Res Commun. 2018 Jun 7;500(3):583-588
• All: 1 reference(s)