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Inavatm1.1Itl
Targeted Allele Detail
Summary
Symbol: Inavatm1.1Itl
Name: innate immunity activator; targeted mutation 1,1, inGenious Targeting Laboratory
MGI ID: MGI:6356370
Synonyms: C1orf106-
Gene: Inava  Location: Chr1:136141269-136162002 bp, - strand  Genetic Position: Chr1, 59.61 cM, cytoband F
Alliance: Inavatm1.1Itl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:257317
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-8 were replaced with a loxP-flanked neomycin selection cassette. The neo cassette was removed via Cre-mediated recombination. Immunoblot analysis confirmed the absence of protein expression in intestinal epithelial monolayers derived from organoids and intestinal epithelial cells isolated from the colon of homozygous mutant mice. (J:257317)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129S6/SvEvTac * C57BL/6NTac
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
cellular
increased cell migration
digestive/alimentary system
abnormal intestinal epithelium morphology
abnormal intestinal epithelium physiology
increased susceptibility to induced colitis
homeostasis/metabolism
abnormal protein level
immune system
increased susceptibility to induced colitis
increased susceptibility to bacterial infection
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Inava Mutation:  38 strains or lines available
References
Original:  J:257317 Mohanan V, et al., C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018 Mar 9;359(6380):1161-1166
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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