Rln3^{tm1.1(cre/GFP)Et}
Targeted Allele Detail

Summary

• Symbol: Rln3^{tm1.1(cre/GFP)Et}
• Name: relaxin 3; targeted mutation 1.1, Eric Turner
• MGI ID: MGI:6356529
• Gene: Rln3 Location: Chr8:84769696-84771608 bp, - strand Genetic Position: Chr8, 40.26 cM
• Alliance: Rln3^{tm1.1(cre/GFP)Et} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302432
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Rln3^{tm1.1(cre/GFP)Et} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rln3 (MGI:2158015)

• Mutation details: The targeting vector contained, from 5' to 3', an internal ribosome entry site sequence (IRES), a Cre/GFP fusion protein sequence and a frt-flanked neo cassette inserted into the 3'UTR in exon 2 of the relaxin 3 gene (Rln3) on chromosome 8. Chimeric mice were bred to FLPe mice for removal of the neo cassette. (J:302432)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rln3 (mouse) Summary of all recombinase alleles driven by Rln3. Comparative matrix view of recombinase activities Alliance mouse Rln3 gene page

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rln3 Mutation: 5 strains or lines available

References

• Original: J:302432 Nasirova N, et al., Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus. eNeuro. 2020 Nov/Dec;7(6):ENEURO.0272-20.2020
• All: 1 reference(s)