Crls1^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Crls1^tm1Geno
• Name: cardiolipin synthase 1; targeted mutation 1, Genoway
• MGI ID: MGI:6356533
• Synonyms: Crls1^f
• Gene: Crls1 Location: Chr2:132688586-132708705 bp, + strand Genetic Position: Chr2, 64.77 cM, cytoband F3
• Alliance: Crls1^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266083
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 4, which contains part of the CDP-alcohol phosphatidyltransferase domain, was flanked by loxP sites. Cre-mediated deletion of exon 4 disrupts the enzymatic domain of CRLS1 and results in out-of-frame splicing and premature stop codons. (J:266083)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crls1 Mutation: 16 strains or lines available

References

• Original: J:266083 Sustarsic EG, et al., Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metab. 2018 Jul 3;28(1):159-174.e11
• All: 2 reference(s)