Nnat^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Nnat^tm1.1Geno
• Name: neuronatin; targeted mutation 1.1, Genoway
• MGI ID: MGI:6356534
• Gene: Nnat Location: Chr2:157401998-157404442 bp, + strand Genetic Position: Chr2, 78.4 cM, cytoband H1
• Alliance: Nnat^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265677
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced flanking exon 1 of the gene, with a neomycin cassette flanked by FRT sites used as a selectable marker. Flp-mediated excision removed the neomycin selection cassette. (J:265677)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nnat Mutation: 15 strains or lines available

References

• Original: J:265677 Millership SJ, et al., Neuronatin regulates pancreatic beta cell insulin content and secretion. J Clin Invest. 2018 Aug 1;128(8):3369-3381
• All: 1 reference(s)