Mad2l1bp^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Mad2l1bp^tm1.2Itl
• Name: MAD2L1 binding protein; targeted mutation 1.2, Ingenious Trageting Laboratory
• MGI ID: MGI:6356611
• Synonyms: Mad2l1bp^-, p31^-
• Gene: Mad2l1bp Location: Chr17:46458311-46464477 bp, - strand Genetic Position: Chr17, 22.88 cM
• Alliance: Mad2l1bp^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234643
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was deleted in the germline via Cre-mediated recombination of flanking loxP sites. Immunoblot analysis confirmed the absence of protein in mouse embryonic fibroblasts (MEFs) derived from homozygous mutant mice. (J:234643)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mad2l1bp Mutation: 15 strains or lines available

References

• Original: J:234643 Choi E, et al., Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. Cell. 2016 Jul 28;166(3):567-81
• All: 1 reference(s)