Csde1^tm1Fda
Targeted Allele Detail

Summary

• Symbol: Csde1^tm1Fda
• Name: cold shock domain containing E1, RNA binding; targeted mutation 1, Francois Dautry
• MGI ID: MGI:6356756
• Synonyms: unr^-, Unr^-
• Gene: Csde1 Location: Chr3:102927742-102965502 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Csde1^tm1Fda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275389
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An 8.5-kb genomic region extending from -3300 to +8200 with respect to the major transcription initiation site was replaced with a neomycin selection cassette. This deletion encompasses the minimal promoter, exon 1 and intron 1. RNase protection assays revealed that mRNA accumulation in various heterozygous tissue samples (liver, spleen, muscle, heart, testis, and brain) is about one half of that in wild-type samples. (J:275389)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csde1 Mutation: 77 strains or lines available

References

• Original: J:275389 Boussadia O, et al., Transcription of unr (upstream of N-ras) down-modulates N-ras expression in vivo. FEBS Lett. 1997 Dec 22;420(1):20-4
• All: 2 reference(s)